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Although it is possible that a very low level of CQ efflux is mediated by PfCRT 3D7 in situ, and that the introduction of the L272F mutation abolishes this activity, it is perhaps unlikely that this would result in the 2-fold difference in the CQ IC 50 observed between the 3D7 L272F and 3D7 parasites.

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Last April a (see ) appeared in the Proceedings of the National Academy of Sciences confirming that at least two mutations to the protein PfCRT are required before chloroquine resistance appears in the malaria parasite, as I had surmised in The Edge of Evolution.

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